{"id":945,"date":"2015-02-23T18:54:56","date_gmt":"2015-02-23T18:54:56","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=945"},"modified":"2015-02-24T10:04:37","modified_gmt":"2015-02-24T10:04:37","slug":"revierten-el-lupus-en-ratones","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=945","title":{"rendered":"Revierten efectos del lupus en ratones"},"content":{"rendered":"

Los investigadores dicen que la clave para revertir los s\u00edntomas y manifestaci\u00f3n del lupus puede ser una combinaci\u00f3n de dos medicamentos existentes.<\/strong><\/span><\/h1>\n
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\"Los\u00a0El lupus es una enfermedad autoinmune cr\u00f3nica que puede da\u00f1ar cualquier parte del cuerpo, desde la piel a las articulaciones pasando por los \u00f3rganos.<\/div>\n

No hay cura para el lupus. Es una enfermedad que act\u00faa por brotes y luego parece desaparecer antes de regresar de nuevo.<\/p>\n

Pero los investigadores dicen que han descubierto que mediante el uso de una combinaci\u00f3n de dos f\u00e1rmacos que ya existen, es posible revertir los efectos del lupus en ratones.<\/span><\/strong><\/p>\n

En un nuevo estudio publicado en\u00a0Science Translational Medicine<\/a>\u00a0,<\/em>\u00a0los investigadores de la Universidad de Florida, Gainesville, han descubierto que mediante la inhibici\u00f3n de ciertas v\u00edas metab\u00f3licas en las c\u00e9lulas inmunes que es posible combatir el lupus en ratones. Los investigadores de la UF Health pueden haber encontrado una manera de controlar el lupus cambiando la forma en que las c\u00e9lulas del sistema inmunol\u00f3gico usan la energ\u00eda.<\/p>\n

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\u00abEl resultado m\u00e1s sorprendente de este estudio fue que la combinaci\u00f3n de los dos inhibidores metab\u00f3licos eran necesarios para revertir la enfermedad\u00bb.\u00a0Dr. Laurence Morel, Universidad de Florida Colegio de Medicina<\/span><\/strong><\/div>\n<\/blockquote>\n
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El lupus eritematoso sist\u00e9mico\u00a0o<\/em>\u00a0lupus, es una enfermedad autoinmune en la que el sistema inmune – que se supone debe proteger el cuerpo contra invasores externos – ataca los propios tejidos del cuerpo, causando inflamaci\u00f3n. El Lupus a veces puede tener s\u00edntomas similares a la artritis.<\/p>\n

Uno de los marcadores de lupus son las c\u00e9lulas T CD4 (c\u00e9lulas blancas de la sangre que activan otras c\u00e9lulas inmunes). \u00a0Para las personas con lupus, el metabolismo de las c\u00e9lulas T es hiperactiva. \u00a0Las c\u00e9lulas T hiper-activadas implican un aumento de la inflamaci\u00f3n, y esto significa m\u00e1s da\u00f1o f\u00edsico. \u00a0Cuando los investigadores bloquearon el metabolismo de la glucosa mediante el uso de un inhibidor de la glucosa, la metformina (tratamiento com\u00fan en diabetes tipo 2), las c\u00e9lulas T CD4 vuelven a la actividad normal (el metabolismo de las T CD4 se ralentiza) y los s\u00edntomas de lupus se invirtieron. \u00a0\u00abSi la c\u00e9lula T es normal, la enfermedad se pone mejor\u00bb<\/em>, dijo Morel.<\/p>\n

El equipo de investigaci\u00f3n inicialmente tuvo la idea de usar un ataque de dos frentes sobre lupus despu\u00e9s de ver un enfoque similar en la investigaci\u00f3n realizada en el c\u00e1ncer, dijo Dr. Laurence Morel, director de patolog\u00eda experimental y profesor de patolog\u00eda, inmunolog\u00eda y medicina de laboratorio en el UF College of Medicine.<\/p>\n

\u00abSi funciona para limitar el metabolismo de las c\u00e9lulas cancerosas, deber\u00eda funcionar para limitar el metabolismo en las c\u00e9lulas T\u00bb<\/em>, dijo el Dr.Morel.<\/p>\n

La eficacia de la metformina en la restauraci\u00f3n de la funci\u00f3n normal de las c\u00e9lulas T cuando se estudian en el laboratorio tambi\u00e9n es un buen augurio para su potencial aplicaci\u00f3n en el futuro para el tratamiento de los pacientes con lupus.<\/p>\n

\u00abEso sugiere que tambi\u00e9n podemos utilizar inhibidores metab\u00f3licos para el tratamiento de los pacientes<\/em>\u00ab, dijo Morel. \u00abEs la primera vez que se ha demostrado que se puede tener un efecto sobre los s\u00edntomas y la manifestaci\u00f3n del lupus mediante la normalizaci\u00f3n del metabolismo celular.<\/em>\u00bb<\/p>\n

Los dos f\u00e1rmacos usados en la investigaci\u00f3n en este estudio hab\u00edan demostrado que inhiben las v\u00edas metab\u00f3licas antes, pero la combinaci\u00f3n parece ser la clave del \u00e9xito.<\/p>\n

\u00abEl resultado m\u00e1s sorprendente de este estudio fue que la combinaci\u00f3n de los dos inhibidores metab\u00f3licos eran necesarios para revertir la enfermedad, cuando se podr\u00eda haber predicho, basado en modelos publicados por otras personas que uno solo iba a funcionar\u00bb<\/em>, dijo el coautor del estudio, Dr.Laurence Morel, director de patolog\u00eda experimental y profesor de patolog\u00eda, inmunolog\u00eda y medicina de laboratorio en la Universidad de Florida College of Medicine.<\/p>\n

Entre otros investigadores que trabajaron en el proyecto est\u00e1n: \u00a0Dr. Eric S. Sobel, profesor asociado de reumatolog\u00eda e inmunolog\u00eda cl\u00ednica; Dr. Byron P. Croker, profesor de patolog\u00eda renal y quir\u00fargico;\u00a0y Dr.Todd Brusko, profesor adjunto en el UF Diabetes Institute,\u00a0departamento de patolog\u00eda, inmunolog\u00eda y laboratorio m\u00e9dico.<\/p>\n

Su investigaci\u00f3n fue financiada por becas de el\u00a0National Institute of Health y la Alliance for Lupus Research.<\/p>\n

Informaci\u00f3n aparecida en \u00a0Healthline<\/a>\u00a0y en\u00a0Medical News Today<\/a>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Los investigadores dicen que la clave para revertir los s\u00edntomas y manifestaci\u00f3n del lupus puede ser una combinaci\u00f3n de dos medicamentos existentes. \u00a0El lupus es una enfermedad autoinmune cr\u00f3nica que puede da\u00f1ar cualquier parte del cuerpo, desde la piel a las articulaciones pasando por los \u00f3rganos. No hay cura para el lupus. Es una enfermedad […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[6,5],"tags":[42,16],"class_list":["post-945","post","type-post","status-publish","format-standard","hentry","category-investigacion","category-lupus-internacional","tag-investigacion","tag-tratamientos"],"yoast_head":"\r\nRevierten efectos del lupus en ratones - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=945\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Revierten efectos del lupus en ratones - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Los investigadores dicen que la clave para revertir los s\u00edntomas y manifestaci\u00f3n del lupus puede ser una combinaci\u00f3n de dos medicamentos existentes. \u00a0El lupus es una enfermedad autoinmune cr\u00f3nica que puede da\u00f1ar cualquier parte del cuerpo, desde la piel a las articulaciones pasando por los \u00f3rganos. 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