{"id":925,"date":"2015-01-26T16:43:46","date_gmt":"2015-01-26T16:43:46","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=925"},"modified":"2015-01-26T16:43:46","modified_gmt":"2015-01-26T16:43:46","slug":"otro-estudio-vuelve-a-involucrar-a-los-clostridio","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=925","title":{"rendered":"Otro estudio vuelve a involucrar a los Clostridio"},"content":{"rendered":"<h1 itemprop=\"headline\">Microbios intestinales desencadenan en enfermedad autoinmune en la vida de ratones cuando son m\u00e1s viejos.<\/h1>\n<p>Los investigadores han revelado que en ratones j\u00f3venes, la colonizaci\u00f3n del intestino por ciertos tipos de bacterias pueden provocar respuestas inmunes m\u00e1s tarde en sus vidas, que est\u00e1n vinculadas a la enfermedad.\u00a0Los aumentos en los niveles de bacterias filamentosas segmentadas pueden desencadenar cambios en el tejido linf\u00e1tico del intestino de rat\u00f3n que acaba produciendo anticuerpos que atacan a los componentes del n\u00facleo de la c\u00e9lula.\u00a0Este tipo de da\u00f1o es una caracter\u00edstica de las enfermedades autoinmunes como el lupus eritematoso sist\u00e9mico\u00a0y \u00a0la esclerosis sist\u00e9mica.\u00a0Los resultados se publican en\u00a0<a href=\"http:\/\/emboj.embopress.org\/\"><em>The EMBO Journal<\/em>\u00a0<\/a>.<\/p>\n<p>\u00ab<em>Nuestros resultados demuestran c\u00f3mo la salud intestinal en animales j\u00f3venes puede estar ligada a la enfermedad autoinmune en animales de mayor edad\u00bb<\/em>, dice Dirk Elewaut, profesor del Ghent University Hospita, en B\u00e9lgica y uno de los autores principales del estudio.\u00a0\u00ab<em>El microbioma de los j\u00f3venes ratones sufren una p\u00e9rdida de la tolerancia del sistema inmune&#8230; El ataque de ciertas prote\u00ednas por el sistema inmunol\u00f3gico del cuerpo, posteriormente, puede conducir a da\u00f1os en los tejidos y a la enfermedad<\/em>.\u00bb<\/p>\n<p>Los investigadores utilizaron ratones en los que los \u00f3rganos linf\u00e1ticos secundarios eran necesarios para sus estudios. \u00a0Los \u00f3rganos linf\u00e1ticos secundarios son: los ganglios linf\u00e1ticos, las am\u00edgdalas, el bazo y otras estructuras donde los linfocitos ( gl\u00f3bulos blancos que desempe\u00f1an papeles esenciales en el sistema inmunol\u00f3gico del cuerpo) \u00a0se activan. Los ratones fueron elaborados interfiriendo con linfotoxina y Hox11, dos prote\u00ednas esenciales que participan en la respuesta autoinmune de los animales.\u00a0Los cient\u00edficos demostraron que aproximadamente un cuarto de ratones modificados de esta manera desarrollaron, espont\u00e1neamente, anticuerpos que atacaron los componentes del n\u00facleo de la c\u00e9lula.\u00a0Este aumento de las reacciones inmunes no deseadas, autoinfligidas fue influenciado por la presencia de bacterias filamentosas segmentadas en el intestino de los ratones m\u00e1s j\u00f3venes.\u00a0Bacterias filamentosas segmentadas son microorganismos relacionados con clostridios que se encuentran en el intestino de muchos animales, incluyendo ratones, ratas y seres humanos.<\/p>\n<p>\u00ab<em>Hemos demostrado un v\u00ednculo entre el microbioma de ratones j\u00f3venes y la aparici\u00f3n posterior de la enfermedad autoinmune<\/em>\u00ab, dice Elewaut.\u00a0\u00abE<em>s necesario seguir trabajando para establecer los mecanismos moleculares precisos que conducen a la aparici\u00f3n de enfermedades como el lupus eritematoso sist\u00e9mico y esclerosis sist\u00e9mica en humanos, pero ahora tenemos una nueva v\u00eda de investigaci\u00f3n que podemos perseguir y buscar posibles intervenciones.<\/em>\u00bb<\/p>\n<p><a href=\"http:\/\/www.medicalnewstoday.com\/releases\/288171.php\">Medical News Today<\/a><\/p>\n<p><a href=\"http:\/\/www.embo.org\/news\/research-news\/research-news-2015\/gut-microbes-trigger-autoimmune-disease-later-in-life-in-mice\">EMBO<\/a><\/p>\n<p><a href=\"http:\/\/www.sciencedaily.com\/releases\/2015\/01\/150119082952.htm\">Science Daily<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Microbios intestinales desencadenan en enfermedad autoinmune en la vida de ratones cuando son m\u00e1s viejos. Los investigadores han revelado que en ratones j\u00f3venes, la colonizaci\u00f3n del intestino por ciertos tipos de bacterias pueden provocar respuestas inmunes m\u00e1s tarde en sus vidas, que est\u00e1n vinculadas a la enfermedad.\u00a0Los aumentos en los niveles de bacterias filamentosas segmentadas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[6,5],"tags":[43,44],"class_list":["post-925","post","type-post","status-publish","format-standard","hentry","category-investigacion","category-lupus-internacional","tag-curiosidades","tag-estudios"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Otro estudio vuelve a involucrar a los Clostridio - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=925\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Otro estudio vuelve a involucrar a los Clostridio - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Microbios intestinales desencadenan en enfermedad autoinmune en la vida de ratones cuando son m\u00e1s viejos. 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