{"id":677,"date":"2014-10-16T10:02:30","date_gmt":"2014-10-16T10:02:30","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=677"},"modified":"2014-10-16T10:02:30","modified_gmt":"2014-10-16T10:02:30","slug":"vacuna-en-estudio","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=677","title":{"rendered":"Vacuna en estudio"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"color: #800080;\">Una vacuna de p\u00e9ptidos en fase de investigaci\u00f3n puede ayudar a normalizar la funci\u00f3n inmunol\u00f3gica en pacientes con lupus eritematoso sist\u00e9mico (LES)<\/span><\/p>\n<p>Los epitopos pept\u00eddicos\u00a0de histona\u00a0\u00a0cumplen con los requisitos para una vacuna, seg\u00fan dicen los investigadores ya que:<\/p>\n<p>\u2022 No son t\u00f3xicos, ya que son derivados de prote\u00ednas propias del cuerpo que se utilizan para \u00abeducar\u00bb al sistema inmunol\u00f3gico durante el desarrollo;<br \/>\n\u2022 Suprimen la producci\u00f3n de autoanticuerpos pat\u00f3genos y la inflamaci\u00f3n renal\u00a0<em>in vivo;<\/em><br \/>\n\u2022 Pueden generar larga duraci\u00f3n, Tregs (C\u00e9lulas T reguladoras) espec\u00edficas de ant\u00edgeno que suprimen patolog\u00eda de la enfermedad;<br \/>\n\u2022 Se puede inducir la reactividad cruzada, tal vez la suprimiendo un amplio espectro de la respuesta autoinmune en el LES;<br \/>\n\u2022 Puede generar c\u00e9lulas T reguladoras (Tregs) en los pacientes con LES, incluso en presencia de hidroxicloroquina o esteroides, o en suero l\u00fapico que contenga interfer\u00f3n de tipo I (IFN).<\/p>\n<p><em>\u00abEn general, el hecho de que incluso las personas sanas pueden tener mecanismos de regulaci\u00f3n contra autoant\u00edgenos nucleares impulsadas por los p\u00e9ptidos histonas sugiere la posibilidad de vacunar a personas aparentemente sanas en riesgo de lupus con estos p\u00e9ptidos<\/em>\u00ab, afirman los autores.<\/p>\n<p>A\u00f1aden que los ep\u00edtopos pept\u00eddicos de histonas \u00abpodr\u00edan tener mecanismos \u00fanicos y hasta ahora no caracterizados por sus efectos inmunorreguladores potentes.\u00bb<\/p>\n<p>M\u00e1s informaci\u00f3n en <a href=\"http:\/\/www.rheumatologynetwork.com\/lupus\/dna-packaging-proteins-may-hold-key-lupus-vaccine\">Rheumatology network<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Una vacuna de p\u00e9ptidos en fase de investigaci\u00f3n puede ayudar a normalizar la funci\u00f3n inmunol\u00f3gica en pacientes con lupus eritematoso sist\u00e9mico (LES) Los epitopos pept\u00eddicos\u00a0de histona\u00a0\u00a0cumplen con los requisitos para una vacuna, seg\u00fan dicen los investigadores ya que: \u2022 No son t\u00f3xicos, ya que son derivados de prote\u00ednas propias del cuerpo que se utilizan para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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