{"id":613,"date":"2014-10-05T20:35:31","date_gmt":"2014-10-05T20:35:31","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=613"},"modified":"2014-10-05T20:40:06","modified_gmt":"2014-10-05T20:40:06","slug":"csic-abre-nuevas-vias-investigacion-para-lupus","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=613","title":{"rendered":"CSIC abre nuevas v\u00edas investigaci\u00f3n para lupus."},"content":{"rendered":"<h1 style=\"text-align: center;\"><span style=\"color: #800080;\">Un estudio liderado por el CSIC abre nuevas v\u00edas de tratamiento para el lupus<\/span><\/h1>\n<h2><em><span style=\"color: #ff6600;\">Una investigaci\u00f3n liderada por el Consejo Superior de Investigaciones Cient\u00edficas (CSIC) ha establecido el perfil de la microbiota, es decir, el conjunto de microorganismos que habitan en un ecosistema determinado, en heces de pacientes con Lupus Eritematoso Sist\u00e9mico. El estudio, publicado en la revista\u00a0mBio, abre nuevas v\u00edas de tratamiento para una afecci\u00f3n que sufren entre 40.000 y 50.000 personas en Espa\u00f1a, seg\u00fan la Federaci\u00f3n Espa\u00f1ola de Lupus<\/span><\/em><\/h2>\n<p>El lupus es una enfermedad autoinmune cr\u00f3nica en la que intervienen factores gen\u00e9ticos, hormonales y ambientales, y que suele darse en mujeres en edad f\u00e9rtil (entre los 15 y los 44 a\u00f1os), de hecho, nueve de cada diez afectados son mujeres. Puede afectar a numerosos \u00f3rganos y tejidos, presentando adem\u00e1s gran variedad de s\u00edntomas cl\u00ednicos, como manifestaciones cut\u00e1neas, articulares y renales. En la actualidad, los tratamientos existentes se centran en el control de los s\u00edntomas y de la respuesta inmune de los pacientes.<\/p>\n<p>\u201c<em><span style=\"color: #800080;\">A trav\u00e9s de t\u00e9cnicas de secuenciaci\u00f3n masiva y an\u00e1lisis bioinform\u00e1ticos, los investigadores hemos comprobado que existen diferencias significativas entre las poblaciones microbianas en individuos sanos y en personas con lupus<\/span><\/em>\u201d, explica el investigador del CSIC Abelardo Margolles, del Instituto de Productos L\u00e1cteos de Asturias. El estudio refleja un desequilibrio en la ratio de los dos grupos de microorganismos m\u00e1s abundantes en el intestino humano: los\u00a0<i>Bacteroidetes<\/i>\u00a0y los\u00a0<i>Firmicutes<\/i>. En los pacientes con lupus se ha detectado que son m\u00e1s abundantes los\u00a0<i>Bacteroidetes<\/i>. Estos resultados son similares a los obtenidos en investigaciones de patolog\u00edas como diabetes tipo 2 y algunas enfermedades inflamatorias intestinales.<\/p>\n<p>\u201c<span style=\"color: #800080;\"><em>La importancia del estudio radica en que nuestros resultados abren nuevas v\u00edas para intentar actuar sobre la sintomatolog\u00eda del lupus<\/em><\/span>\u201d, explica el investigador. \u201c<em><span style=\"color: #800080;\">Por ejemplo, se sabe que a trav\u00e9s de una intervenci\u00f3n diet\u00e9tica se puede modificar el contenido de la microbiota intestinal, favoreciendo el incremento de poblaciones determinadas de microorganismos. De este modo, se puede facilitar el aumento de la poblaci\u00f3n de bacterias poco abundantes en los enfermos de lupus y, quiz\u00e1, modificar la respuesta inmune de los pacientes<\/span><\/em>\u201d.<\/p>\n<p><span style=\"letter-spacing: 0.1em;\">En el estudio, coordinado por investigadores del Instituto de Productos L\u00e1cteos de Asturias,\u00a0han participado tambi\u00e9n las Universidades de Oviedo y de Parma (Italia).<\/span><\/p>\n<ul>\n<li>\n<pre><span style=\"color: #ff6600;\">A. Hevia, C. Milani, P. L\u00f3pez, A. Cuervo, S. Arboleya, S. Duranti, F. Turroni, S. Gonz\u00e1lez, A. Su\u00e1rez, M. Gueimonde, M. Ventura, B. S\u00e1nchez y A. Margolles.\u00a0<b style=\"color: #000000; font-size: medium; font-style: normal;\">Intestinal dysbiosis associated with Systemic Lupus Erythematosus<\/b>.\u00a0<i style=\"color: #000000; font-size: medium;\">mBio<\/i>\u00a0DOI: 10.1128\/mBio.01548-14<\/span><\/pre>\n<\/li>\n<\/ul>\n<p>Noticia tomada del <a href=\"http:\/\/www.csic.es\/web\/guest\/home?p_p_id=contentviewerservice_WAR_alfresco_packportlet&amp;p_p_lifecycle=1&amp;p_p_state=maximized&amp;p_p_mode=view&amp;p_p_col_id=column-1-2&amp;p_p_col_count=2&amp;_contentviewerservice_WAR_alfresco_packportlet_struts_action=\/contentviewer\/view&amp;_contentviewerservice_WAR_alfresco_packportlet_nodeRef=workspace:\/\/SpacesStore\/49f900e4-f3a6-4a0d-a087-c46c257d8474&amp;_contentviewerservice_WAR_alfresco_packportlet_gsa_index=false&amp;_contentviewerservice_WAR_alfresco_packportlet_title=noticias&amp;contentType=news\">CSIC<\/a><\/p>\n<p><a href=\"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/CSIC-nota-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-616\" alt=\"CSIC nota 1\" src=\"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/CSIC-nota-1-224x300.jpg\" width=\"224\" height=\"300\" srcset=\"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/CSIC-nota-1-224x300.jpg 224w, https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/CSIC-nota-1.jpg 421w\" sizes=\"auto, (max-width: 224px) 100vw, 224px\" \/><\/a>\u00a0\u00a0<a href=\"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/Csic-nota2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-617\" alt=\"Csic nota2\" src=\"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/Csic-nota2-300x279.jpg\" width=\"300\" height=\"279\" srcset=\"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/Csic-nota2-300x279.jpg 300w, https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/Csic-nota2-322x300.jpg 322w, https:\/\/lupusgalicia.org\/wp-content\/uploads\/2014\/10\/Csic-nota2.jpg 417w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudio liderado por el CSIC abre nuevas v\u00edas de tratamiento para el lupus Una investigaci\u00f3n liderada por el Consejo Superior de Investigaciones Cient\u00edficas (CSIC) ha establecido el perfil de la microbiota, es decir, el conjunto de microorganismos que habitan en un ecosistema determinado, en heces de pacientes con Lupus Eritematoso Sist\u00e9mico. El estudio, publicado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[6],"tags":[44],"class_list":["post-613","post","type-post","status-publish","format-standard","hentry","category-investigacion","tag-estudios"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>CSIC abre nuevas v\u00edas investigaci\u00f3n para lupus. - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=613\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"CSIC abre nuevas v\u00edas investigaci\u00f3n para lupus. - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Un estudio liderado por el CSIC abre nuevas v\u00edas de tratamiento para el lupus Una investigaci\u00f3n liderada por el Consejo Superior de Investigaciones Cient\u00edficas (CSIC) ha establecido el perfil de la microbiota, es decir, el conjunto de microorganismos que habitan en un ecosistema determinado, en heces de pacientes con Lupus Eritematoso Sist\u00e9mico. 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