{"id":513,"date":"2014-07-18T14:17:59","date_gmt":"2014-07-18T14:17:59","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=513"},"modified":"2014-07-18T14:17:59","modified_gmt":"2014-07-18T14:17:59","slug":"el-lupus-se-agrava-cuando-el-anti-dsdna-el-tlr4-y-el-tlr9-cooperan","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=513","title":{"rendered":"El Lupus se agrava cuando el Anti-dsDNA, el TLR4 y el TLR9 cooperan."},"content":{"rendered":"<h1><span style=\"color: #800080;\"><span style=\"font-weight: bold;\">\u00a0<\/span>Los resultados parecen abrir una l\u00ednea de terapia nueva.<\/span><\/h1>\n<p>El\u00a0<span style=\"color: #800080;\"><a title=\"\u00bfQu\u00e9 es el lupus?\" href=\"https:\/\/translate.googleusercontent.com\/translate_c?act=url&amp;depth=1&amp;hl=es&amp;ie=UTF8&amp;prev=_t&amp;rurl=translate.google.es&amp;sl=en&amp;tl=es&amp;u=http:\/\/www.medicalnewstoday.com\/info\/lupus\/&amp;usg=ALkJrhiq2AlzhWdCkLBZrWRXYqkEQxcpHQ\"><span style=\"color: #800080;\">lupus<\/span><\/a>\u00a0eritematoso sist\u00e9mico<\/span> (LES) es una enfermedad autoinmune multifactorial complicada e influenciada por muchos factores gen\u00e9ticos y ambientales.\u00a0El sello <b>distintivo del lupus eritematoso sist\u00e9mico (LES) es la presencia de altos niveles de autoanticuerpos anti-ADN de doble cadena (anti-dsDNA)<\/b> en los sueros.<\/p>\n<p>Adem\u00e1s, las mayores tasas de infecci\u00f3n se encuentran en pacientes con LES y una mayor morbilidad y mortalidad suelen provenir de infecciones bacterianas.<\/p>\n<p>Descifrar las interacciones entre los genes de susceptibilidad y los factores ambientales de los rasgos complejos lupus es un reto y se ha traducido en un \u00e9xito limitado.<\/p>\n<p>En la edici\u00f3n de junio de\u00a0<strong><i>Biolog\u00eda y Medicina Experimental<\/i>\u00a0<\/strong>, <strong><span style=\"color: #800080;\">el Dr. Lee y colaboradores, de la Universidad Nacional Yang-Ming de Taiw\u00e1n, estudiaron el papel del anti-ADN de doble cadena (anti-dsDNA ) y los receptores tipo Toll (TLR), TLR4 y TLR9, en la patog\u00e9nesis del lupus.\u00a0<\/span><\/strong>Prepararon los ratones transg\u00e9nicos que llevan el transg\u00e9n anti-dsDNA y desafiaron a estos ratones con TLR4 y TLR9 agonistas.\u00a0Ellos demuestran que en los ratones transg\u00e9nicos anti-dsADN TLR4 y TLR9 est\u00e1n conjuntamente vinculados a la progresi\u00f3n del lupus.<\/p>\n<p><i>\u00bb <span style=\"color: #800080;\">Dado que la activaci\u00f3n simult\u00e1nea de los receptores de reconocimiento de patrones extracelulares e intracelulares (PRR) puede disparar respuestas inmunes m\u00e1s intensas, es realmente crucial determinar si la co-participaci\u00f3n de ellos puede aumentar la gravedad de la enfermedad en el lupus\u00bb<\/span><\/i> dijo el Dr. Kuang-Hui Sun, uno de los autores.<\/p>\n<h2>\u00a0Estos resultados sugieren que la selecci\u00f3n simult\u00e1nea de anticuerpos anti-ADN de doble cadena, TLR4 y TLR9 puede ser una terapia potencial para el LES.<\/h2>\n<p>M\u00e1s informaci\u00f3n en <a href=\"http:\/\/www.medicalnewstoday.com\/releases\/278237.php\">Medical News Today\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0Los resultados parecen abrir una l\u00ednea de terapia nueva. El\u00a0lupus\u00a0eritematoso sist\u00e9mico (LES) es una enfermedad autoinmune multifactorial complicada e influenciada por muchos factores gen\u00e9ticos y ambientales.\u00a0El sello distintivo del lupus eritematoso sist\u00e9mico (LES) es la presencia de altos niveles de autoanticuerpos anti-ADN de doble cadena (anti-dsDNA) en los sueros. Adem\u00e1s, las mayores tasas de infecci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14,6],"tags":[16],"class_list":["post-513","post","type-post","status-publish","format-standard","hentry","category-estudios","category-investigacion","tag-tratamientos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>El Lupus se agrava cuando el Anti-dsDNA, el TLR4 y el TLR9 cooperan. - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=513\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"El Lupus se agrava cuando el Anti-dsDNA, el TLR4 y el TLR9 cooperan. - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"\u00a0Los resultados parecen abrir una l\u00ednea de terapia nueva. 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