{"id":511,"date":"2014-07-18T14:14:25","date_gmt":"2014-07-18T14:14:25","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=511"},"modified":"2014-07-18T14:14:25","modified_gmt":"2014-07-18T14:14:25","slug":"roquin-en-estudio","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=511","title":{"rendered":"Roquin en estudio"},"content":{"rendered":"<h1>Con el estudio de Roquin se intenta comprender los mecanismos moleculares de las enfermedades autoinmunes.<\/h1>\n<p>Los cient\u00edficos del Helmholtz Zentrum M\u00fcnchen, de la Universidad Ludwig-Maximilians de Munich (LMU) y la Technische Universit\u00e4t M\u00fcnchen (TUM) han dado un paso importante para estar m\u00e1s cerca de comprender los mecanismos moleculares de las enfermedades autoinmunes.<\/p>\n<p>Resolvieron la estructura tridimensional de la prote\u00edna Roquin cuando se une a \u00e1cido ribonucleico mensajero (ARNm).\u00a0Los resultados revelaron que existe una gama mucho m\u00e1s amplia de socios vinculados a Roquin funcionalmente importantes de lo que se supon\u00eda anteriormente.\u00a0Los nuevos hallazgos aparecen publicados en la revista\u00a0<i>Nature Structural &amp; Molecular Biology.<\/i><\/p>\n<h1 style=\"text-align: center;\"><strong><span style=\"color: #800080;\">La prote\u00edna Roquin, descubierta en 2005, controla la activaci\u00f3n de c\u00e9lulas T y la diferenciaci\u00f3n mediante la regulaci\u00f3n de la expresi\u00f3n de ciertos mRNAs.\u00a0<\/span><\/strong><\/h1>\n<p><strong><\/strong>De este modo, ayuda a garantizar la tolerancia inmunol\u00f3gica y evita las respuestas inmunes contra los propios estructuras del cuerpo que pueden conducir a la enfermedad autoinmune.<\/p>\n<p><strong><span style=\"text-decoration: underline;\"><span style=\"color: #800080; text-decoration: underline;\">Roquin e<\/span><\/span><span style=\"text-decoration: underline;\"><span style=\"color: #800080; text-decoration: underline;\">s, pues, un regulator autoimmune de enfermedades inmunitarias<\/span> <\/span><\/strong>que afectan a la poblaci\u00f3n entre 5-10%.\u00a0Por lo general estas enfermedades aparecen como resultado de influencias ambientales complejas cuando existe una predisposici\u00f3n gen\u00e9tica.\u00a0S\u00f3lo en casos raros el desarrollo de la enfermedad se determina por un solo gen mutado. Sin embargo, una \u00fanica mutaci\u00f3n en el gen Roquin en un modelo de rat\u00f3n se demostr\u00f3 que era responsable del desarrollo de la enfermedad autoinmune: <strong><span style=\"color: #800080;\"><a title=\"\u00bfQu\u00e9 es el lupus?\" href=\"https:\/\/translate.googleusercontent.com\/translate_c?act=url&amp;depth=1&amp;hl=es&amp;ie=UTF8&amp;prev=_t&amp;rurl=translate.google.es&amp;sl=en&amp;tl=es&amp;u=http:\/\/www.medicalnewstoday.com\/info\/lupus\/&amp;usg=ALkJrhiq2AlzhWdCkLBZrWRXYqkEQxcpHQ\"><span style=\"color: #800080;\">lupus<\/span><\/a>\u00a0eritematoso sist\u00e9mico.\u00a0<\/span><\/strong><\/p>\n<p>Esta mutaci\u00f3n en la prote\u00edna Roquin tambi\u00e9n condujo a una alta susceptibilidad a la <strong>diabetes tipo 1,\u00a0 a la artritis reumatoide y al linfoma inducido por las c\u00e9lulas T angioinmunobl\u00e1sticas.<\/strong><\/p>\n<h2 style=\"text-align: center;\"><span style=\"color: #800080;\"><b>La explicaci\u00f3n de la estructura tridimensional del complejo Roquin-ARN<\/b>\u00a0<\/span><\/h2>\n<p>Un equipo interdisciplinar formado por los grupos de investigaci\u00f3n dirigido por el Prof. Michael Sattler, el Dr. Dierk Niessing y el Prof. Vigo Heissmeyer en el Helmholtz Zentrum M\u00fcnchen, de la Universidad Ludwig-Maximilian (LMU) y la Technische Universit\u00e4t M\u00fcnchen (TUM) ha revelado una visi\u00f3n sin precedentes de c\u00f3mo Roquin reconoce el ARN y realiza su uni\u00f3n y as\u00ed controla las funciones de las c\u00e9lulas T.<\/p>\n<p>Para ello, los cient\u00edficos Dr. Andreas Schlundt, Gitta Heinz, y el Dr. Robert Janowski utilizan una plataforma cristalogr\u00e1fica de rayos X para determinar la estructura espacial de dicho complejo.\u00a0La interacci\u00f3n de Roquin con ARN y parejas de uni\u00f3n adicionales se estudi\u00f3 en soluci\u00f3n utilizando la resonancia magn\u00e9tica nuclear (RMN).\u00a0Adem\u00e1s, los investigadores pudieron confirmar la importancia biol\u00f3gica del reconocimiento molecular del ARN mediante el estudio de la regulaci\u00f3n de genes Roquin-dependientes en los sistemas celulares.<\/p>\n<p>Los resultados obtenidos ponen de manifiesto por primera vez las interacciones moleculares por las que Roquin reconoce en el ARNm de un gen, un motivo de uni\u00f3n.\u00a0\u00ab<i><span style=\"text-decoration: underline;\">Para nuestra sorpresa, estos resultados indican que hay una mayor variedad de modos de uni\u00f3n que juegan un papel funcional importante en la regulaci\u00f3n gen\u00e9tica de las c\u00e9lulas T\u00bb<\/span>, <\/i>dice el <span style=\"color: #800080;\">Prof. Michael Sattler<\/span>.\u00a0\u00ab<span style=\"text-decoration: underline;\"><i>Por lo tanto, nuestros resultados sugieren que Roquin regula un mayor n\u00famero de genes de lo que se supon\u00eda anteriormente<\/i>\u00ab,<\/span> a\u00f1ade<span style=\"color: #800080;\"> el Dr. Niessing.\u00a0<\/span><\/p>\n<p>Adem\u00e1s de los ARNm que se une fuertemente y est\u00e1n regulados por Roquin, hay un n\u00famero potencialmente mucho m\u00e1s grande de ARNms que est\u00e1n unidos m\u00e1s d\u00e9bilmente pero tambi\u00e9n son regulados por Roquin.\u00a0<i>\u00ab<span style=\"text-decoration: underline;\">Sobre la base de estas conclusiones, ahora nos vamos a centrar en la comprensi\u00f3n de c\u00f3mo los niveles de Roquin est\u00e1n reguladas en las c\u00e9lulas T, ya sea su uni\u00f3n con ARNms fuerte o d\u00e9bil y c\u00f3mo experimentan una regulaci\u00f3n diferente cuando la disponibilidad de esta prote\u00edna var\u00eda\u00bb<\/span>, <\/i>explica el <span style=\"color: #800080;\">Prof. Vigo Heissmeyer.<\/span><\/p>\n<h2 style=\"text-align: center;\"><span style=\"color: #800080;\"><b>Bases para el desarrollo de un tratamiento<\/b><\/span><\/h2>\n<p>Definir la interacci\u00f3n molecular entre Roquin y el ARN es un requisito previo para con-trolar la funci\u00f3n de Roquin y usar su papel en estrategias terap\u00e9uticas para el tratamiento de enfermedades autoinmunes.\u00a0Por ello, los cient\u00edficos est\u00e1n planteando estudios de seguimiento para averiguar c\u00f3mo la funci\u00f3n de Roquin puede ser manipulada.<\/p>\n<p>M\u00e1s informaci\u00f3n en <a href=\"http:\/\/www.medicalnewstoday.com\/releases\/279622.php\">Medical News Today\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Con el estudio de Roquin se intenta comprender los mecanismos moleculares de las enfermedades autoinmunes. Los cient\u00edficos del Helmholtz Zentrum M\u00fcnchen, de la Universidad Ludwig-Maximilians de Munich (LMU) y la Technische Universit\u00e4t M\u00fcnchen (TUM) han dado un paso importante para estar m\u00e1s cerca de comprender los mecanismos moleculares de las enfermedades autoinmunes. Resolvieron la estructura [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14,6],"tags":[16],"class_list":["post-511","post","type-post","status-publish","format-standard","hentry","category-estudios","category-investigacion","tag-tratamientos"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Roquin en estudio  - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=511\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Roquin en estudio  - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Con el estudio de Roquin se intenta comprender los mecanismos moleculares de las enfermedades autoinmunes. Los cient\u00edficos del Helmholtz Zentrum M\u00fcnchen, de la Universidad Ludwig-Maximilians de Munich (LMU) y la Technische Universit\u00e4t M\u00fcnchen (TUM) han dado un paso importante para estar m\u00e1s cerca de comprender los mecanismos moleculares de las enfermedades autoinmunes. Resolvieron la estructura [&hellip;]\" \/>\r\n<meta property=\"og:url\" content=\"https:\/\/lupusgalicia.org\/?p=511\" \/>\r\n<meta property=\"og:site_name\" content=\"Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/LupusGalicia\/\" \/>\r\n<meta property=\"article:published_time\" content=\"2014-07-18T14:14:25+00:00\" \/>\r\n<meta name=\"author\" content=\"Agal\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:creator\" content=\"@LupusGalicia\" \/>\r\n<meta name=\"twitter:site\" content=\"@LupusGalicia\" \/>\r\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Agal\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutos\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/lupusgalicia.org\/?p=511#article\",\"isPartOf\":{\"@id\":\"https:\/\/lupusgalicia.org\/?p=511\"},\"author\":{\"name\":\"Agal\",\"@id\":\"https:\/\/lupusgalicia.org\/#\/schema\/person\/4c5a48f33530bf5afca090219ff56665\"},\"headline\":\"Roquin en estudio\",\"datePublished\":\"2014-07-18T14:14:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/lupusgalicia.org\/?p=511\"},\"wordCount\":729,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/lupusgalicia.org\/#organization\"},\"keywords\":[\"Tratamientos\"],\"articleSection\":[\"Estudios\",\"Investigaci\u00f3n\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/lupusgalicia.org\/?p=511#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lupusgalicia.org\/?p=511\",\"url\":\"https:\/\/lupusgalicia.org\/?p=511\",\"name\":\"Roquin en estudio - Asociaci\u00f3n Galega de Lupus\",\"isPartOf\":{\"@id\":\"https:\/\/lupusgalicia.org\/#website\"},\"datePublished\":\"2014-07-18T14:14:25+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lupusgalicia.org\/?p=511#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lupusgalicia.org\/?p=511\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lupusgalicia.org\/?p=511#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\/\/lupusgalicia.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Roquin en estudio\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lupusgalicia.org\/#website\",\"url\":\"https:\/\/lupusgalicia.org\/\",\"name\":\"Asociaci\u00f3n Galega de Lupus\",\"description\":\"Trabajando para y por las personas con Lupus\",\"publisher\":{\"@id\":\"https:\/\/lupusgalicia.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lupusgalicia.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/lupusgalicia.org\/#organization\",\"name\":\"Asociaci\u00f3n Galega de Lupus\",\"url\":\"https:\/\/lupusgalicia.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/lupusgalicia.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2023\/06\/AGAL-scaled.png\",\"contentUrl\":\"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2023\/06\/AGAL-scaled.png\",\"width\":2560,\"height\":2522,\"caption\":\"Asociaci\u00f3n Galega de Lupus\"},\"image\":{\"@id\":\"https:\/\/lupusgalicia.org\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/LupusGalicia\/\",\"https:\/\/x.com\/LupusGalicia\",\"https:\/\/www.instagram.com\/lupusgalicia\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/lupusgalicia.org\/#\/schema\/person\/4c5a48f33530bf5afca090219ff56665\",\"name\":\"Agal\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/7f60df48bf4a5a797270581c89811177b4ff71b18f397a910784a9bfc7025e33?s=96&d=mm&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/7f60df48bf4a5a797270581c89811177b4ff71b18f397a910784a9bfc7025e33?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/7f60df48bf4a5a797270581c89811177b4ff71b18f397a910784a9bfc7025e33?s=96&d=mm&r=g\",\"caption\":\"Agal\"},\"description\":\"AGAL. Asociaci\u00f3n Galega de Lupus. Creada en 1997. Pretendemos dar informaci\u00f3n sobre el Lupus y que la enfermedad deje de ser una gran desconocida; ayudar a familiares y amigos; promover investigaci\u00f3n; divulgar y relacionar a nuestros asociados a trav\u00e9s de Jornadas, la revista Papilio, charlas, reuniones...\",\"sameAs\":[\"http:\/\/www.lupusgalicia.org\"],\"url\":\"https:\/\/lupusgalicia.org\/?author=1\"}]}<\/script>\r\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Roquin en estudio  - Asociaci\u00f3n Galega de Lupus","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lupusgalicia.org\/?p=511","og_locale":"es_ES","og_type":"article","og_title":"Roquin en estudio  - Asociaci\u00f3n Galega de Lupus","og_description":"Con el estudio de Roquin se intenta comprender los mecanismos moleculares de las enfermedades autoinmunes. Los cient\u00edficos del Helmholtz Zentrum M\u00fcnchen, de la Universidad Ludwig-Maximilians de Munich (LMU) y la Technische Universit\u00e4t M\u00fcnchen (TUM) han dado un paso importante para estar m\u00e1s cerca de comprender los mecanismos moleculares de las enfermedades autoinmunes. Resolvieron la estructura [&hellip;]","og_url":"https:\/\/lupusgalicia.org\/?p=511","og_site_name":"Asociaci\u00f3n Galega de Lupus","article_publisher":"https:\/\/www.facebook.com\/LupusGalicia\/","article_published_time":"2014-07-18T14:14:25+00:00","author":"Agal","twitter_card":"summary_large_image","twitter_creator":"@LupusGalicia","twitter_site":"@LupusGalicia","twitter_misc":{"Escrito por":"Agal","Tiempo de lectura":"4 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/lupusgalicia.org\/?p=511#article","isPartOf":{"@id":"https:\/\/lupusgalicia.org\/?p=511"},"author":{"name":"Agal","@id":"https:\/\/lupusgalicia.org\/#\/schema\/person\/4c5a48f33530bf5afca090219ff56665"},"headline":"Roquin en estudio","datePublished":"2014-07-18T14:14:25+00:00","mainEntityOfPage":{"@id":"https:\/\/lupusgalicia.org\/?p=511"},"wordCount":729,"commentCount":0,"publisher":{"@id":"https:\/\/lupusgalicia.org\/#organization"},"keywords":["Tratamientos"],"articleSection":["Estudios","Investigaci\u00f3n"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/lupusgalicia.org\/?p=511#respond"]}]},{"@type":"WebPage","@id":"https:\/\/lupusgalicia.org\/?p=511","url":"https:\/\/lupusgalicia.org\/?p=511","name":"Roquin en estudio - Asociaci\u00f3n Galega de Lupus","isPartOf":{"@id":"https:\/\/lupusgalicia.org\/#website"},"datePublished":"2014-07-18T14:14:25+00:00","breadcrumb":{"@id":"https:\/\/lupusgalicia.org\/?p=511#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/lupusgalicia.org\/?p=511"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/lupusgalicia.org\/?p=511#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/lupusgalicia.org\/"},{"@type":"ListItem","position":2,"name":"Roquin en estudio"}]},{"@type":"WebSite","@id":"https:\/\/lupusgalicia.org\/#website","url":"https:\/\/lupusgalicia.org\/","name":"Asociaci\u00f3n Galega de Lupus","description":"Trabajando para y por las personas con Lupus","publisher":{"@id":"https:\/\/lupusgalicia.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lupusgalicia.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/lupusgalicia.org\/#organization","name":"Asociaci\u00f3n Galega de Lupus","url":"https:\/\/lupusgalicia.org\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/lupusgalicia.org\/#\/schema\/logo\/image\/","url":"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2023\/06\/AGAL-scaled.png","contentUrl":"https:\/\/lupusgalicia.org\/wp-content\/uploads\/2023\/06\/AGAL-scaled.png","width":2560,"height":2522,"caption":"Asociaci\u00f3n Galega de Lupus"},"image":{"@id":"https:\/\/lupusgalicia.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/LupusGalicia\/","https:\/\/x.com\/LupusGalicia","https:\/\/www.instagram.com\/lupusgalicia\/"]},{"@type":"Person","@id":"https:\/\/lupusgalicia.org\/#\/schema\/person\/4c5a48f33530bf5afca090219ff56665","name":"Agal","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/secure.gravatar.com\/avatar\/7f60df48bf4a5a797270581c89811177b4ff71b18f397a910784a9bfc7025e33?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/7f60df48bf4a5a797270581c89811177b4ff71b18f397a910784a9bfc7025e33?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7f60df48bf4a5a797270581c89811177b4ff71b18f397a910784a9bfc7025e33?s=96&d=mm&r=g","caption":"Agal"},"description":"AGAL. Asociaci\u00f3n Galega de Lupus. Creada en 1997. Pretendemos dar informaci\u00f3n sobre el Lupus y que la enfermedad deje de ser una gran desconocida; ayudar a familiares y amigos; promover investigaci\u00f3n; divulgar y relacionar a nuestros asociados a trav\u00e9s de Jornadas, la revista Papilio, charlas, reuniones...","sameAs":["http:\/\/www.lupusgalicia.org"],"url":"https:\/\/lupusgalicia.org\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=\/wp\/v2\/posts\/511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=511"}],"version-history":[{"count":1,"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=\/wp\/v2\/posts\/511\/revisions"}],"predecessor-version":[{"id":512,"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=\/wp\/v2\/posts\/511\/revisions\/512"}],"wp:attachment":[{"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lupusgalicia.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}