{"id":2818,"date":"2021-12-02T15:22:53","date_gmt":"2021-12-02T13:22:53","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=2818"},"modified":"2021-12-02T15:27:49","modified_gmt":"2021-12-02T13:27:49","slug":"las-pastillas-antivirales-para-el-covid-19","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=2818","title":{"rendered":"Las pastillas antivirales para el COVID-19"},"content":{"rendered":"\n

Las grandes farmac\u00e9uticas Merck y Pfizer est\u00e1n ultimando sus pastillas para reducir el virus en sus primeros d\u00edas de sintomatolog\u00eda. Un remedio fant\u00e1stico siempre que tengamos tests de covid f\u00e1ciles de usar y baratos a disposici\u00f3n de todo el mundo.<\/p>\n\n\n\n

A principios de noviembre Pfizer anunciaba su antiviral Paxlovid (ritonavir) de uso oral y unas semanas despu\u00e9s Merck daba los resultados de la suya Molnupiravir. <\/p>\n\n\n\n

Las dos tienen en com\u00fan que se usan como preventivo para evitar complicaciones en pacientes con alto riesgo de padecer un COVID severo. Adem\u00e1s se pueden tomar en casa sin tener que ingresar en un centro para su aplicaci\u00f3n, lo que las hace m\u00e1s pr\u00e1cticas. Habr\u00eda que tomarlas en los primeros d\u00edas de infecci\u00f3n porque lo que evitan es que el virus crezca en nuestro cuerpo y produzca las inflamaciones masivas que son el verdadero problema para nuestra vida.<\/p>\n\n\n\n

Ambas est\u00e1n en fases avanzadas de sus ensayos cl\u00ednicos y fueron probadas en pacientes con factores de alto riesgo de tener un covid severo y que estaban en un estado temprano de infecci\u00f3n observando su evoluci\u00f3n a muerte u hospitalizaci\u00f3n. El Molnupiravir reduce ese riesgo al 50% tomada en los 5 primeros d\u00edas de s\u00edntomas. El Paxlovid reduce el riesgo en un 89% en los 3 primeros d\u00edas de s\u00edntomas y un 85% en los 5 primeros d\u00edas. Ning\u00fan paciente que tomo cualquiera de los dos medicaciones muri\u00f3 durante el estudio. <\/p>\n\n\n\n

\"\"<\/a>
Ciclo vital del SARS-CoV-2 y los retrovirales de Merck y Pfizer<\/figcaption><\/figure>\n\n\n\n

MOLNUPIRAVIR<\/p>\n\n\n\n

El virus SARS-CoV-2 almacena la informaci\u00f3n para crear r\u00e9plicas en las ramas de ARN . Cuando llega a nuestras c\u00e9lulas el virus hace copias de ese ARN. El <\/strong>Molnupiravir (de Merck) se camufla como si fuese una de las mol\u00e9culas llave y el virus lo incorpora dentro de la cadena de ARN. Cuando la rama del ARN que contiene el Molnupiravir es copiada produce errores en las copias. Tras m\u00faltiples copias , intentos y errores llega un momento que el virus no puede seguir por un \u00aberror catastr\u00f3fico\u00bb. <\/p>\n\n\n\n

PAXLOVID<\/p>\n\n\n\n

El mecanismo para evitar la replicaci\u00f3n del virus con el Paxlovid de Pfizer es diferente. El SARS-CoV-2 crea unas prote\u00ednas que son necesarias para construir nuevos virus con una larga cadena llamada poliprote\u00edna. El virus tiene que cortar las poliprote\u00ednas en segmentos m\u00e1s cortos para poder activarlas y las corta con una enzima de proteasa. El Paxlovid lo que hace es bloquear la proteasa v\u00edrica y de esta manera el virus no puede completar su c\u00edrculo vital.<\/p>\n\n\n\n

POSIBILIDADES<\/p>\n\n\n\n

Hace unas semanas Gran Breta\u00f1a aprob\u00f3 el uso de la Molnupiravir aunque solo es efectivo antes de la hospitalizaci\u00f3n mientras que Estados Unidos ha comprado millones de dosis de ambas medicaciones en espera de su autorizaci\u00f3n por la FDA para su utilizaci\u00f3n. <\/p>\n\n\n\n

Hay m\u00e1s medicamentos antivirales, en concreto 268. Tienes informaci\u00f3n actualizada de las vacunas, tratamientos y antivirales en desarrollo: BIO COVID-19 Therapeutic Development Tracker<\/em><\/strong><\/a>. Entre ellos est\u00e1 el remdesivir oral o los anticuerpos monoclonales inyectables. Tambi\u00e9n se est\u00e1n estudiando medicamentos que ya existen como la Budesonida (corticoide) para inhalar o la Fluvoxamina (antidepresivo) que parecen prometedores. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n\n\n\n

Art\u00edculo de Ignacio L\u00f3pez-Go\u00f1i en su blog <\/a>El autor es Catedr\u00e1tico de Microbiolog\u00eda en la Universidad de Navarra. Tambi\u00e9n pod\u00e9is leer el art\u00edculo relacionado aparecido en The Conversation <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Las grandes farmac\u00e9uticas Merck y Pfizer est\u00e1n ultimando sus pastillas para reducir el virus en sus primeros d\u00edas de sintomatolog\u00eda. Un remedio fant\u00e1stico siempre que tengamos tests de covid f\u00e1ciles de usar y baratos a disposici\u00f3n de todo el mundo. A principios de noviembre Pfizer anunciaba su antiviral Paxlovid (ritonavir) de uso oral y unas […]<\/p>\n","protected":false},"author":1,"featured_media":2822,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[3,77,79],"tags":[81,44,19,16],"class_list":["post-2818","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agal","category-covid19","category-medicacion","tag-covid","tag-estudios","tag-informacion","tag-tratamientos"],"yoast_head":"\r\nLas pastillas antivirales para el COVID-19 - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=2818\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Las pastillas antivirales para el COVID-19 - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Las grandes farmac\u00e9uticas Merck y Pfizer est\u00e1n ultimando sus pastillas para reducir el virus en sus primeros d\u00edas de sintomatolog\u00eda. 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