{"id":1365,"date":"2015-10-29T00:22:20","date_gmt":"2015-10-28T22:22:20","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=1365"},"modified":"2015-10-29T00:22:20","modified_gmt":"2015-10-28T22:22:20","slug":"descifrado-el-mapa-genetico-del-lupus-mas-completo-logrado-hasta-la-fecha","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=1365","title":{"rendered":"Descifrado el mapa gen\u00e9tico del lupus m\u00e1s completo logrado hasta la fecha"},"content":{"rendered":"<h1 class=\"subtitulo\" style=\"text-align: center;\"><span style=\"color: #800080;\">Este avance cient\u00edfico abre las puertas al desarrollo de nuevos tratamientos m\u00e9dicos m\u00e1s eficaces<\/span><\/h1>\n<p>Un equipo internacional de<strong> cient\u00edficos <\/strong>en el que participa la\u00a0<strong>Universidad de Granada <\/strong>ha descifrado el<strong> mapa gen\u00e9tico <\/strong>m\u00e1s completo hasta la fecha del <strong>lupus eritematoso sist\u00e9mico<\/strong>, una\u00a0<strong>enfermedad cr\u00f3nica <\/strong>y autoinmune que en la actualidad no tiene cura.<\/p>\n<p>Este avance cient\u00edfico abre las puertas al desarrollo de nuevos tratamientos m\u00e9dicos m\u00e1s eficaces y personalizados contra el lupus, ya que permite clasificar a los pacientes en funci\u00f3n de su perfil gen\u00e9tico y de acuerdo a las variantes de riesgo que tienen, seg\u00fan ha informado hoy la Universidad de Granada.<\/p>\n<p>Se trata, seg\u00fan la Universidad, del estudio m\u00e1s completo realizado hasta la fecha en gen\u00e9tica del lupus eritematoso sist\u00e9mico, e incluye meta-an\u00e1lisis con dos cohortes m\u00e1s de la enfermedad.<\/p>\n<p>En \u00e9l ha participado Marta Alarc\u00f3n Riquelme, investigadora del Centro Pfizer-Universidad de Granada-Junta de Andaluc\u00eda de Gen\u00f3mica e Investigaci\u00f3n Oncol\u00f3gica (Genyo).<\/p>\n<p>Junto con el profesor Timothy J Vyse, del King&#8217;s College de Londres, la cient\u00edfica de la Universidad de Granada ha llevado a cabo el genotipado de 4.500 pacientes diagnosticados con lupus eritematoso sist\u00e9mico y de 1.200 pacientes sanos que ejercieron como grupo control.<\/p>\n<p>Los investigadores tomaron datos de controles sanos de la base del\u00a0<strong>NIH dbGaP<\/strong>, una base de datos mundial de genotipos y fenotipos.<\/p>\n<p>Hasta ahora, el n\u00famero de genes identificados para el lupus eritematoso sist\u00e9mico sobrepasa los 50, y en este estudio los investigadores han logrado identificar otros 12 novedosos.<\/p>\n<p>Tambi\u00e9n se ha descubierto, seg\u00fan Alarc\u00f3n, que entre esos genes hay \u00abun enriquecimiento de factores de transcripci\u00f3n, genes que regulan la expresi\u00f3n de otros genes\u00bb.<\/p>\n<p>Adem\u00e1s, muestran los tipos celulares donde estos genes est\u00e1n llevando a cabo sus efectos. En la actualidad, el lupus eritematoso tiene una prevalencia del 0,05%, y afecta especialmente a mujeres en\u00a0<strong>edad reproductiva<\/strong>, con una <strong>alta mortalidad<\/strong>.<\/p>\n<p>Este proyecto europeo, que arranc\u00f3 en el 2014, estudiar\u00e1 durante cinco a\u00f1os m\u00e1s <strong>2.000 pacientes <\/strong>con diversas enfermedades: lupus eritematoso sist\u00e9mico, esclerosis sist\u00e9mica, s\u00edndrome de Sj\u00f6gren, s\u00edndrome antifosfolip\u00eddico o la enfermedad mixta del tejido conjuntivo.<\/p>\n<p>Noticia aparecida en <a href=\"http:\/\/www.elperiodico.com\/es\/noticias\/sanidad\/descifrado-mapa-genetico-del-lupus-mas-completo-logrado-hasta-fecha-4621270\">El Peri\u00f3dico\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Este avance cient\u00edfico abre las puertas al desarrollo de nuevos tratamientos m\u00e9dicos m\u00e1s eficaces Un equipo internacional de cient\u00edficos en el que participa la\u00a0Universidad de Granada ha descifrado el mapa gen\u00e9tico m\u00e1s completo hasta la fecha del lupus eritematoso sist\u00e9mico, una\u00a0enfermedad cr\u00f3nica y autoinmune que en la actualidad no tiene cura. Este avance cient\u00edfico abre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[6,5,24],"tags":[42],"class_list":["post-1365","post","type-post","status-publish","format-standard","hentry","category-investigacion","category-lupus-internacional","category-mujer-lupica","tag-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>Descifrado el mapa gen\u00e9tico del lupus m\u00e1s completo logrado hasta la fecha - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=1365\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Descifrado el mapa gen\u00e9tico del lupus m\u00e1s completo logrado hasta la fecha - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Este avance cient\u00edfico abre las puertas al desarrollo de nuevos tratamientos m\u00e9dicos m\u00e1s eficaces Un equipo internacional de cient\u00edficos en el que participa la\u00a0Universidad de Granada ha descifrado el mapa gen\u00e9tico m\u00e1s completo hasta la fecha del lupus eritematoso sist\u00e9mico, una\u00a0enfermedad cr\u00f3nica y autoinmune que en la actualidad no tiene cura. 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