{"id":1307,"date":"2015-09-25T10:09:21","date_gmt":"2015-09-25T08:09:21","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=1307"},"modified":"2015-09-27T13:19:15","modified_gmt":"2015-09-27T11:19:15","slug":"las-grasas-saturadas-podrian-aumentar-inflamacion-y-dano-tisular","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=1307","title":{"rendered":"Las grasas saturadas podr\u00edan aumentar inflamaci\u00f3n y da\u00f1o tisular"},"content":{"rendered":"

Los altos niveles de grasas saturadas en la sangre podr\u00edan hacer a una persona m\u00e1s propensa a la inflamaci\u00f3n\u00a0y al da\u00f1o tisular, sugiere un estudio reciente.<\/span><\/h1>\n

Una nueva investigaci\u00f3n apoya la idea de que el consumo excesivo de grasas saturadas puede ser malo para nosotros.<\/span><\/p>\n

Cient\u00edficos del Imperial College London estudiaron ratones con\u00a0un nivel inusualmente alto de grasa saturada en sangre.<\/span> La investigaci\u00f3n, publicada el 3 de septiembre de 2015 en Cell Reports<\/em><\/strong> muestra la presencia de grasas saturadas en monocitos – un tipo de gl\u00f3bulo blanco – que migran a\u00a0tejidos de \u00f3rganos vitales.<\/span><\/p>\n

Los investigadores creen que los monocitos inmigrantes\u00a0podr\u00edan empeorar el da\u00f1o tisular, ya que pueden agravar la inflamaci\u00f3n en curso o subyacente, pero este aspecto sigue siendo objeto de estudio.<\/span><\/p>\n

El investigador principal, \u00a0Dr. Kevin Woollard<\/span> <\/strong>dijo: \u00a0\u00abLos ratones que estudiamos fueron tratados con un medicamento que produce acumulaci\u00f3n en\u00a0niveles extremadamente altos de grasa en sangre. Aunque es inusual, los seres humanos a veces tienen mediciones que se acercan a esos niveles, ya sea debido a una condici\u00f3n hereditaria o por comer muchos alimentos grasos\u00bb.<\/em><\/span><\/span><\/p>\n

\u00a0\u00abEl estilo de vida moderno parecen ir de la mano\u00a0con altos niveles de grasa en sangre. Esta grasa proviene de los alimentos y bebidas que consumimos, por ejemplo, usted se sorprender\u00eda de la cantidad de grasa saturada que hay en un capuchino y algunas personas beben varios a lo largo\u00a0del d\u00eda.\u00bb<\/span><\/em><\/span><\/p>\n

\"12186340-juego-de-dulces-brillantes-en-estilo-dibujo\"<\/a> \"6245940_s\"<\/a><\/p>\n

\u00abCreemos que mantener\u00a0una concentraci\u00f3n relativamente alta de grasas saturadas, por ejemplo, mediante la ingesta constante de pasteles, galletas, boller\u00eda … podr\u00edan ser la causa de que los monocitos emigren\u00a0fuera de la sangre \u00a0 \u00a0 \u00a0 \u00a0 \u00a0hacia\u00a0los tejidos circundantes.\u00bb<\/span><\/em><\/h4>\n

La sangre mantiene un equilibrio muy sutil. El intercambio de c\u00e9lulas y otras sustancias de la sangre con el tejido circundante es parte del mantenimiento de ese equilibrio.<\/span><\/p>\n

El equipo, dirigido por el Dr. Woollard y la profesora Marina Botto, del Departamento de Medicina del Imperial College de Londres, ha observado que a medida que los \u00f3rganos toman grasas, la mayor\u00eda de los monocitos migrados se convierten en otro tipo de c\u00e9lula inmune llamada macr\u00f3fagos y algunas de las c\u00e9lulas situadas dentro de los tejidos toman grasa y se convierten en \u00abc\u00e9lulas espumosas\u00bb.<\/span> Estas c\u00e9lulas espumosas y las macr\u00f3fagos estimulan la producci\u00f3n de una mol\u00e9cula de se\u00f1alizaci\u00f3n llamada CCL4, que atrae a m\u00e1s monocitos al tejido.<\/span> Esta espiral contin\u00faa mientras el nivel de grasa saturada es elevada.<\/span><\/p>\n

Estos mecanismos pueden haberse desarrollado para eliminar las grasas de la sangre con el fin de mantener un equilibrio saludable;<\/span>\u00a0se requiere m\u00e1s investigaci\u00f3n para confirmar esto.<\/span><\/p>\n

Un descubrimiento fundamental, sin embargo, es que los monocitos que est\u00e1n involucrados en este acto de equilibrio son de un tipo muy espec\u00edfico.<\/span><\/p>\n

Dr Woollard dijo: \u00abEs muy emocionante ver que los monocitos que migran hacia los tejidos son todos de un mismo tipo y eso significa que en realidad podr\u00edamos ser capaces de desarrollar medicamentos que cambien este comportamiento.\u00bb<\/em><\/span><\/span><\/p>\n

En el futuro, las personas que est\u00e1n en riesgo de enfermedad cardiovascular o que son obesos podr\u00edan ser tratados con un f\u00e1rmaco terap\u00e9utico que se dirige a estos monocitos particulares y evita el posible da\u00f1o futuro causado por la acumulaci\u00f3n de grasa en sus vasos sangu\u00edneos y \u00f3rganos.<\/span><\/p>\n

\u00abCuriosamente, las personas con ciertos trastornos del sistema inmune que afecta a los monocitos, incluyendo algunas enfermedades inflamatorias y autoinmunes, como el lupus\u00a0<\/span>pueden tener inesperadamente altos niveles de grasas saturadas en la sangre y tambi\u00e9n son m\u00e1s propensos a sufrir \u00a0ataques de coraz\u00f3n y\/o derrames cerebrales\u00a0a una edad m\u00e1s joven.\u00bb<\/span><\/strong><\/em><\/span><\/p>\n

Las pr\u00f3ximas etapas de esta investigaci\u00f3n ser\u00e1n estudiar grupos de pacientes con enfermedades inflamatorias, y mirar los efectos directos de los alimentos saturados en funci\u00f3n de los monocitos.<\/span><\/p>\n

Noticia aparecida en Medical News Today<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Los altos niveles de grasas saturadas en la sangre podr\u00edan hacer a una persona m\u00e1s propensa a la inflamaci\u00f3n\u00a0y al da\u00f1o tisular, sugiere un estudio reciente. Una nueva investigaci\u00f3n apoya la idea de que el consumo excesivo de grasas saturadas puede ser malo para nosotros. Cient\u00edficos del Imperial College London estudiaron ratones con\u00a0un nivel inusualmente […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14,24],"tags":[41,44,42],"class_list":["post-1307","post","type-post","status-publish","format-standard","hentry","category-estudios","category-mujer-lupica","tag-alimentacion","tag-estudios","tag-investigacion"],"yoast_head":"\r\nLas grasas saturadas podr\u00edan aumentar inflamaci\u00f3n y da\u00f1o tisular - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=1307\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Las grasas saturadas podr\u00edan aumentar inflamaci\u00f3n y da\u00f1o tisular - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Los altos niveles de grasas saturadas en la sangre podr\u00edan hacer a una persona m\u00e1s propensa a la inflamaci\u00f3n\u00a0y al da\u00f1o tisular, sugiere un estudio reciente. 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Una nueva investigaci\u00f3n apoya la idea de que el consumo excesivo de grasas saturadas puede ser malo para nosotros. 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