{"id":1301,"date":"2015-09-25T01:10:03","date_gmt":"2015-09-24T23:10:03","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=1301"},"modified":"2015-09-27T01:23:58","modified_gmt":"2015-09-26T23:23:58","slug":"salud-osea-vitamina-d-y-lupus","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=1301","title":{"rendered":"Salud \u00f3sea, vitamina D y lupus"},"content":{"rendered":"

Los pacientes con lupus eritematoso sist\u00e9mico presentan una prevalencia elevada de deficiencia e insuficiencia de vitamina D. <\/strong><\/span><\/h1>\n

Esto se debe probablemente a las medidas de fotoprotecci\u00f3n y a factores intr\u00ednsecos de la enfermedad. Los niveles bajos de vitamina D aumentan el riesgo de presentar una densidad mineral \u00f3sea reducida y de fractura. El d\u00e9ficit de vitamina D podr\u00eda tambi\u00e9n tener efectos no deseados sobre la respuesta inmune de los pacientes, potenciando mecanismos de p\u00e9rdida de tolerancia y autoinmunidad. Los niveles de vitamina D deber\u00edan ser monitorizados peri\u00f3dicamente y los pacientes deber\u00edan ser tratados con el objetivo de alcanzar unos niveles de vitamina D superiores a 30-40 ng\/ml.<\/span><\/h2>\n

 <\/p>\n

La vitamina D es una hormona esteroidea que desempe\u00f1a un papel crucial en el metabolismo fosfoc\u00e1lcico y en la homeostasis del hueso a trav\u00e9s de la interacci\u00f3n con la gl\u00e1ndula paratiroides, el ri\u00f1\u00f3n y el intestino.<\/p>\n

\"67721-saludosea\"<\/a><\/p>\n

Numerosos estudios en diferentes regiones del mundo han demostrado que la insuficiencia de vitamina D es un problema com\u00fan, frecuente en todas las edades y resultado de la combinaci\u00f3n de una serie de factores como la raza, el grado de exposici\u00f3n solar, la latitud, el envejecimiento y la ingesta de vitamina D. En adici\u00f3n al papel del d\u00e9ficit de la vitamina D en el desarrollo o gravedad de la osteoporosis, se acumula informaci\u00f3n sobre la potencial relaci\u00f3n entre la hipovitaminosis D y diferentes enfermedades autoinmunes, hipertensi\u00f3n arterial o algunos tipos de c\u00e1ncer.\u00a0<\/span>\u00a0Poblaciones alejadas del ecuador presentan un mayor riesgo de desarrollar enfermedades autoinmunes.\u00a0<\/span>Disponemos de evidencia s\u00f3lida sobre la asociaci\u00f3n entre LES o artritis reumatoide y la deficiencia de vitamina D, aunque probablemente tambi\u00e9n exista asociaci\u00f3n con otras enfermedades reum\u00e1ticas inflamatorias cr\u00f3nicas.<\/p>\n

La vitamina D es esencial para muchos tejidos del organismo y est\u00e1 implicada en numerosos procesos biol\u00f3gicos m\u00e1s all\u00e1 del metabolismo \u00f3seo<\/span>.<\/p><\/blockquote>\n

Los pacientes con lupus con frecuencia presentan fotosensibilidad lo que implica un mayor riesgo de desarrollar deficiencia de vitamina D. M\u00faltiples estudios que investigaban la posible asociaci\u00f3n entre la insuficiencia o deficiencia de vitamina D y lupus han puesto de manifiesto que la insuficiencia de vitamina D es un problema muy frecuente en este grupo de pacientes. Son m\u00faltiples los factores potencialmente implicados en el desarrollo de hipovitaminosis D, entre los que se encuentran el consejo de evitar la exposici\u00f3n solar en pacientes con fotosensibilidad; el uso de medidas de fotoprotecci\u00f3n; la insuficiencia renal; el uso prolongado de glucocorticoides, antimal\u00e1ricos o antiepil\u00e9pticos; o la presencia de anticuerpos antivitamina D. Todo esto lleva a la p\u00e9rdida de masa \u00f3sea en el LES. Los pacientes con lupus presentan una densidad mineral \u00f3sea (DMO) reducida y un aumento de riesgo de fractura,<\/span><\/strong> pero son escasos los estudios que eval\u00faan el riesgo de fractura en pacientes con LES.<\/p>\n

A pesar de los numerosos estudios publicados sobre el LES y la vitamina D, una pregunta que queda por responder es si la deficiencia de vitamina D agrava el curso de la enfermedad<\/span><\/strong>. Sobre este punto se han centrado varios estudios de reciente publicaci\u00f3n reflejando cierta inconsistencia en sus conclusiones. Por lo que a\u00fan no se puede afirmar con rotundidad dicha asociaci\u00f3n.<\/p>\n

La deficiencia de vitamina D se ha relacionado con la enfermedad arterial coronaria,<\/span><\/strong> la insuficiencia card\u00edaca y la enfermedad renal. La cardiopat\u00eda isqu\u00e9mica es una causa principal de muerte en los pacientes con LES, por lo que es muy relevante identificar factores asociados al desarrollo de aterosclerosis en los pacientes l\u00fapicos.<\/p>\n

Estudio realizado por\u00a0Clara Sang\u00fcesa G\u00f3mez, Bryan Josu\u00e9 Flores Robles, Jos\u00e9 Luis Andr\u00e9u.<\/h6>\n
Art\u00edculo aparecido en : Reumatolog\u00eda Cl\u00ednica\u00a0<\/a><\/h6>\n","protected":false},"excerpt":{"rendered":"

Los pacientes con lupus eritematoso sist\u00e9mico presentan una prevalencia elevada de deficiencia e insuficiencia de vitamina D. Esto se debe probablemente a las medidas de fotoprotecci\u00f3n y a factores intr\u00ednsecos de la enfermedad. Los niveles bajos de vitamina D aumentan el riesgo de presentar una densidad mineral \u00f3sea reducida y de fractura. El d\u00e9ficit de […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14,24],"tags":[44,38,16],"class_list":["post-1301","post","type-post","status-publish","format-standard","hentry","category-estudios","category-mujer-lupica","tag-estudios","tag-mujer-lupica","tag-tratamientos"],"yoast_head":"\r\nSalud \u00f3sea, vitamina D y lupus - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=1301\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Salud \u00f3sea, vitamina D y lupus - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Los pacientes con lupus eritematoso sist\u00e9mico presentan una prevalencia elevada de deficiencia e insuficiencia de vitamina D. Esto se debe probablemente a las medidas de fotoprotecci\u00f3n y a factores intr\u00ednsecos de la enfermedad. Los niveles bajos de vitamina D aumentan el riesgo de presentar una densidad mineral \u00f3sea reducida y de fractura. 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