{"id":1012,"date":"2015-04-11T01:20:06","date_gmt":"2015-04-10T23:20:06","guid":{"rendered":"http:\/\/lupusgalicia.org\/?p=1012"},"modified":"2015-04-11T02:25:33","modified_gmt":"2015-04-11T00:25:33","slug":"de-camino-hacia-la-vacuna","status":"publish","type":"post","link":"https:\/\/lupusgalicia.org\/?p=1012","title":{"rendered":"\u00bfDe camino hacia la vacuna?"},"content":{"rendered":"

Cient\u00edficos de la Northwestern Medicine han probado con \u00e9xito una terapia no t\u00f3xica que suprime el lupus en muestras de sangre de personas<\/strong> con esta enfermedad autoinmune. Este es un paso positivo hacia el desarrollo, alg\u00fan d\u00eda, de\u00a0una terapia con vacunas que podr\u00eda mantener el lupus en remisi\u00f3n<\/strong> en el cuerpo humano sin el uso de f\u00e1rmacos t\u00f3xicos.<\/span><\/h1>\n

\"Remisi\u00f3n<\/p>\n

El estudio fue publicado en la revista Clinical Immunology<\/em><\/span><\/strong>, la revista de la Federaci\u00f3n de Sociedades de Inmunolog\u00eda Cl\u00ednica<\/span>. El lupus es una enfermedad autoinmune cr\u00f3nica que causa que el cuerpo cree autoanticuerpos que atacan y destruyen el tejido sano, causando inflamaci\u00f3n, dolor y da\u00f1o en varios \u00f3rganos vitales del cuerpo. Seg\u00fan la Lupus Foundation of America, se cree que 5 millones de personas en todo el mundo tienen una forma de lupus<\/strong>.<\/p>\n

En estudios anteriores, los cient\u00edficos de la Northwestern mostraron que un\u00a0tratamiento no t\u00f3xico<\/strong> (que utiliza p\u00e9ptidos sint\u00e9ticos, es decir peque\u00f1os trozos de prote\u00edna, para generar c\u00e9lulas T reguladoras especiales) bloquea el lupus en ratones que son propensos a la enfermedad.<\/p>\n

Para este nuevo estudio, 30 pacientes con lupus <\/strong>(10 activos y 20 en remisi\u00f3n) y 15 pacientes sanos fueron inscritos y sus muestras de sangre se cultivaron en laboratorio con dosis bajas de los p\u00e9ptidos especiales.<\/p>\n

Seg\u00fan dijo Syamal Datta,<\/strong><\/span> autor principal del estudio y profesor de medicina- reumatolog\u00eda y de microbiolog\u00eda-inmunolog\u00eda en la Universidad Northwestern Feinberg School of Medicine:<\/strong><\/p>\n

\u00abHemos encontrado que los p\u00e9ptidos no s\u00f3lo pueden generar c\u00e9lulas T reguladoras, sino tambi\u00e9n bloquear y reducir la producci\u00f3n de autoanticuerpos a niveles casi de base en los cultivos de sangre de las personas con lupus activo\u00bb.<\/span><\/p>\n

\u00abEste enfoque muestra que los p\u00e9ptidos tienen la capacidad de funcionar como una vacuna en el cuerpo humano<\/strong>, para estimular la regulaci\u00f3n del sistema inmunol\u00f3gico de las personas con lupus, para luchar contra los anticuerpos autoinmunes y para mantener la enfermedad en remisi\u00f3n.\u00bb<\/span><\/p><\/blockquote>\n

 <\/p>\n

Los esteroides y el cytoxan son las terapias m\u00e1s comunes<\/strong> que se utilizan para ayudar a tratar a las personas con lupus, e incluso a dosis muy bajas los efectos secundarios de los medicamentos son t\u00f3xicos. Al igual que la quimioterapia, los f\u00e1rmacos para el lupus pueden comprometer la fertilidad y debilitar el sistema inmunol\u00f3gico, dejando sus cuerpos susceptibles a las infecciones. Adem\u00e1s, estos f\u00e1rmacos t\u00f3xicos no se pueden dar de forma indefinida.<\/p>\n

Seg\u00fan dijo Datta:<\/span><\/strong><\/p>\n

\u00abEsta terapia no t\u00f3xica funciona como una vacuna en la que los p\u00e9ptidos han sido reconocidos por los cuerpos de casi todas las personas que hemos visto\u00bb.<\/span><\/p>\n

\u00abPuede ser administrado a ambos sujetos con y sin lupus y mejora su respuesta reguladora, sin efectos secundarios. No tenemos que dise\u00f1ar algo espec\u00edficamente para una persona poco com\u00fan. Funciona en todo el mundo.\u00bb<\/span><\/p>\n

\u00abTenemos la esperanza de que el siguiente paso sea un ensayo cl\u00ednico de fase 1 en humanos para demostrar la eficacia de la terapia con p\u00e9ptidos en pacientes con lupus\u00bb.<\/span><\/p>\n

\u00abLa clave es encontrar un socio industrial que tenga experiencia en este tipo de terapias, para que podamos seguir adelante.\u00bb<\/span><\/p><\/blockquote>\n

<\/h6>\n

This study was supported by funding from Alliance for Lupus Research (TIL grant #187305 to S.K.D.) and the National Institutes of Health (National Institute of Allergy and Infectious Diseases grant, R01AI41985 to S.K.D, and National Institute of Arthritis and Musculoskeletal and Skin Diseases, P60 AR30692 to R. R-G).<\/p>\n

Noticia aparecida en Redpacientes<\/a>\u00a0, tambi\u00e9n en<\/h4>\n

Northwestern University<\/a> y en\u00a0Sciencinewsline<\/a><\/h4>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Cient\u00edficos de la Northwestern Medicine han probado con \u00e9xito una terapia no t\u00f3xica que suprime el lupus en muestras de sangre de personas con esta enfermedad autoinmune. Este es un paso positivo hacia el desarrollo, alg\u00fan d\u00eda, de\u00a0una terapia con vacunas que podr\u00eda mantener el lupus en remisi\u00f3n en el cuerpo humano sin el uso […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[6],"tags":[42],"class_list":["post-1012","post","type-post","status-publish","format-standard","hentry","category-investigacion","tag-investigacion"],"yoast_head":"\r\n\u00bfDe camino hacia la vacuna? - Asociaci\u00f3n Galega de Lupus<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/lupusgalicia.org\/?p=1012\" \/>\r\n<meta property=\"og:locale\" content=\"es_ES\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"\u00bfDe camino hacia la vacuna? - Asociaci\u00f3n Galega de Lupus\" \/>\r\n<meta property=\"og:description\" content=\"Cient\u00edficos de la Northwestern Medicine han probado con \u00e9xito una terapia no t\u00f3xica que suprime el lupus en muestras de sangre de personas con esta enfermedad autoinmune. 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